Efficacy of Binary Media and Gold Catalyst for the Synthesis of a Conjugates with Cyclohexyl-Tetrazole-Alkyloxyphenyl-Benzenamine through Ugi 4-CC Reactions: Cytotoxic and Single-Crystal Studies

With the critical increase in patients suffering from various types of malignant growth, it is obvious that quick steps development novel and viable agents should be taken. In current study, we focused on a synthetic approach for synthesis tetrazole derivatives using Ugi-4CR by employing gold catalyst water: methanol media. Gold’s adjustable nature, unique characteristics, mild reaction conditions were utilized to generate quadrupole adduct containing cyclohexyl system, benzamine, terminal alkyne bearing aryl medicinally efficient fragment. Along with routine characteristic techniques (IR, MS, NMR), single crystal XRD was imparted assumption spatial arrangement desired (5a-5j). Out 10 selected scaffolds NCI 60 cell lines 5b shown their highest potency single-dose assay (10−4 M) against CAKI-1 (GI50= −4.66, Renal cancer) 5e found most active Leukemia (MOLT-4, GI50= −5.37) cancers than rest synthesized molecules.